Influenza A virus infection of primary differentiated airway epithelial cell cultures derived from Syrian golden hamsters.
Identifieur interne : 001484 ( Main/Exploration ); précédent : 001483; suivant : 001485Influenza A virus infection of primary differentiated airway epithelial cell cultures derived from Syrian golden hamsters.
Auteurs : Celeste M. Newby ; Regina K. Rowe ; Andrew Pekosz [États-Unis]Source :
- Virology [ 0042-6822 ] ; 2006.
Abstract
The ability of several different influenza A virus strains to infect and replicate in primary, differentiated airway epithelial cell cultures from Syrian golden hamsters was investigated. All virus strains tested replicated equivalently in the cultures and displayed a preference for infecting nonciliated cells. This tropism correlated with the expression of both α2,3- and α2.,6-linked sialic acid on the nonciliated cells. In contrast, the ciliated cells did not have detectable α2,6-linked sialic acid and expressed only low amounts of α2,3-linked sialic acid. In contrast to clinical isolates, laboratory strains of influenza A virus infected a limited number of ciliated cells at late times post infection. The presence of α2,3- and α2,6-linked sialic acid residues on the same cell type suggests , Syrian golden hamsters and differentiated airway epithelial cell cultures derived from hamsters may provide a system for studying the reassortment of influenza A virus strains which utilize different forms of sialic acid as a primary virus receptor.
Url:
DOI: 10.1016/j.virol.2006.06.024
PubMed: 16876846
PubMed Central: 1704084
Affiliations:
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Rowe</name><affiliation><nlm:aff wicri:cut=" and" id="A1">Depts. of Molecular Microbiology</nlm:aff></affiliation></author><author><name sortKey="Pekosz, Andrew" sort="Pekosz, Andrew" uniqKey="Pekosz A" first="Andrew" last="Pekosz">Andrew Pekosz</name><affiliation><nlm:aff wicri:cut=" and" id="A1">Depts. of Molecular Microbiology</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Pathology & Immunology, Washington University in St. Louis School of Medicine, 660 S.Euclid Ave., Campus Box 8230, St. Louis, MO 63110</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Pathology & Immunology, Washington University in St. Louis School of Medicine, 660 S.Euclid Ave., Campus Box 8230, St. Louis</wicri:cityArea></affiliation></author></analytic><series><title level="j">Virology</title><idno type="ISSN">0042-6822</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The ability of several different influenza A virus strains to infect and replicate in primary, differentiated airway epithelial cell cultures from Syrian golden hamsters was investigated. All virus strains tested replicated equivalently in the cultures and displayed a preference for infecting nonciliated cells. This tropism correlated with the expression of both α2,3- and α2.,6-linked sialic acid on the nonciliated cells. In contrast, the ciliated cells did not have detectable α2,6-linked sialic acid and expressed only low amounts of α2,3-linked sialic acid. In contrast to clinical isolates, laboratory strains of influenza A virus infected a limited number of ciliated cells at late times post infection. The presence of α2,3- and α2,6-linked sialic acid residues on the same cell type suggests , Syrian golden hamsters and differentiated airway epithelial cell cultures derived from hamsters may provide a system for studying the reassortment of influenza A virus strains which utilize different forms of sialic acid as a primary virus receptor.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Missouri (État)</li></region></list><tree><noCountry><name sortKey="Newby, Celeste M" sort="Newby, Celeste M" uniqKey="Newby C" first="Celeste M." last="Newby">Celeste M. Newby</name><name sortKey="Rowe, Regina K" sort="Rowe, Regina K" uniqKey="Rowe R" first="Regina K." last="Rowe">Regina K. Rowe</name></noCountry><country name="États-Unis"><region name="Missouri (État)"><name sortKey="Pekosz, Andrew" sort="Pekosz, Andrew" uniqKey="Pekosz A" first="Andrew" last="Pekosz">Andrew Pekosz</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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